Course Summary (2009)

The most intensely studied topic of brain research has been learning and memory, which has captivated the interest of scientists ever since the biological processes underlying it were accidentally stumbled upon. Since then a determined and unceasing research effort has uncovered many of the secrets.
It is easy to underestimate the importance of learning and memory but it is, above all else, the most important task the brain performs. It is our human brains greater hunger and capacity for learning and memory that separates us from all the other species. As individuals we are the sum of who we are genetically and how the experience, knowledge and skills we acquire shape our outlook on and relationship with the world and inform our choices in life.

Learning and memory come in several different forms, ranging from very complex, long-term, ingrained memories that persist undiminished for all of our lives to short-term memories that are forgotten all too quickly.
Different types of memory have their own distinct character: Acquiring your native language almost unconsciously whilst you are a baby, learning a new language later in life, learning to drive a car, childhood experiences with a dog that paralyze you with fear for years to come, constantly memorizing new information for tests at school and college, remembering where you put your cell phone or someone’s name and phone number.

How does the brain manage to identify and sort these different memories into the many categories then nurture them from 5 seconds to a lifetime, waiting for a signal to recall them in the most minute detail? Individual memory abilities vary greatly and there are famous figures with photographic memories who can recall 5000 playing cards in exact sequence and others who cannot store any long-term memories, where each morning is a strange new world.

Research and experimentation has increased our understanding even to the point that we have discovered ways to manipulate cognitive powers like memory and attentiveness. Likely heralding a new generation of lifestyle drugs to aid ordinary healthy people in over-achieving everyday tasks.

In this course I will define the different forms of memory, teach you the underlying brain systems and explain how these relate to normal life. Additionally, we will look at a variety of neurological and psychiatric diseases such as Schizophrenia, Depression and Alzheimer’s and their roots in these systems.

This course will culminate in a field trip to the world-renowned Marine Biological Laboratory (MBL) at Woods Hole, Cape Cod where I carry out some of my most exciting neurological research. We will spend the day at this seaside resort where we will study live squid, freshly caught in the morning on the MBL fishing boat. Then using one of the most powerful microscopes in the world we will be able to watch inside living brain cells as they carry out the processes that underlie learning and memory.

Students completing this exciting course will gain useful knowledge and insight into how the brain learns, remembers and forgets. We will also explore the methods by which memory and learning can be reliably enhanced, gaining invaluable insight into how to maximize learning and memory potential in study and life.

            Instructor: Dr Andrew P Mallon

            Office: 476, BioMed. 75 Waterman St, Providence.

            Office Hours: 7am-4pm

            Office Phone: 401 315 5979

Email: Andrew_Mallon@brown.edu

                        (Email is, by far, the best way to contact me to ensure a speedy response)

            Class Hours: TBA

 

Course Aims:

Students who complete this course will:

1.      Understand the psychological and behavioral basis of learning and memory.

2.      Learn the underlying biology.

3.      Explore the Neurological and Psychiatric diseases of learning and memory.

4.      Realize the ways in which learning, memory and cognitive powers can be diminished and enhanced.

 

Organization of the course:

 
Teaching Methods, Assignments, and Activities

Each class meeting will have a lecture to explain and expand upon the reading assignments as well as a discussion component.  Students are expected to actively participate in class discussions and activities, based on the background reading, primary journal articles and case studies. Lectures will be made available online.

Reading Materials

The background material presented in this course will be covered in the textbook: Learning and Memory: From Brain to Behavior; Gluck, Mercado and Myers.  Specific chapters will be assigned.

However, this course will also concentrate on recent scientific and clinical discoveries. Learning and memory is a particularly dynamic area of research, with fascinating new discoveries being made and reported every day.  

A detailed handout will be provided for each class including study worksheets.

 
Class Participation

Your appreciation and understanding of the issues will be strongly enhanced through regular attendance and participation in the class. Students are encouraged to read the assigned text prior to class and come prepared to actively participate in class discussions.

Grading: 

Exam 1                                                           25 points                                                                        

Final exam                                                       40 points

Paper and presentation                                     25 points

Lab report                                                       10 points total

 

Paper:  5 pages, with 10 minute presentation

Experimentation

During the course we will assess the variety of ways that learning and memory have been claimed to be enhanced by researchers, commercial companies and others. We will construct a simple experiment that will test the merit of some of these claims and seek to enhance the mental powers of a test group compared to a control group. This exciting component will also teach the students the very important principles of scientific design and analysis.

Group Presentation

The results of our experiments will form the foundation of group presentations. Students will learn how to present and interpret their results. This will teach students the skills required to communicate observed data and evidence in a compelling way that can withstand cynicism.


Field Trip

The summer course will end with an optional field trip to the Marine Biological Laboratory at the picturesque seaside resort town of Woods Hole, in Cape Cod. Students will spend the morning participating in experiments which explore the underlying biology of brain cells of the squid.

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